Variant position: 10 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 115 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MNFALILMI NTLLALLLMIITFWLPQLNGY
Gorilla MNFALILMT NTLLALLLMIITFWLPQLNSY
Chimpanzee MNFVLILMT NTLLALLLMIITFWLPQLNSY
Mouse MNLYTVIFI NILLSLTLILVAFWLPQMNLY
Rat MNLLIIITI NITLSFILISIAFWLPQMNLY
Pig MNIMLTLLT NVTLASLLVLIAFWLPQLNAY
Bovine MNLMLALLT NFTLATLLVIIAFWLPQLNVY
Rabbit MNLMLVLLI NTTISLVLVTIAFWLPQLNIY
Sheep MNLMITLLT NFTLATLLVTIAFWLPQLNVY
Cat MNVMLALLT NTLLSTLLVLIAFWLPQLNIY
Horse MNLMLTLLT NTLLASLLVLIAFWLPQLNIY
Chicken NTLTFMLSL SFLLSAALTTMNFWLAQMAPD
Xenopus laevis -MTATILMI AMTLSTILAILSFWLPQMTPD
Zebrafish NLFATILII MTTLSLVLALVSFWLPQMNSD
Caenorhabditis elegans LVLLMVLVF TLVLLFAFYLINFLLSIKDMG
Drosophila SIIFIALLI LLITTIVMFLASILSKKALID
Slime mold VYILVLLAI STGLSVILFFLGYFLMFKVAY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 115 NADH-ubiquinone oxidoreductase chain 3
3 – 23 Helical
Assignment of a polymorphic polypeptide to the human mitochondrial DNA unidentified reading frame 3 gene by a new peptide mapping strategy.
Oliver N.A.; Greenberg B.D.; Wallace D.C.;
J. Biol. Chem. 258:5834-5839(1983)
Cited for: VARIANTS ASP-10 AND ALA-114;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.