Variant position: 114 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 115 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LIIILALSLAYEWLQKGLDW TE
Gorilla LIIILTLSLAYEWLQKGLDW TE
Chimpanzee LITILALSLAYEWLQKGLDW TE
Mouse LVTILSLGLAYEWTQKGLEW TE
Rat LVTILALGLSYEWTQKGLEW TE
Pig LLILLAASLAYEWTQKGLEW AE
Bovine LIILLAVSLAYEWTQKGLEW TE
Rabbit LISILALGLAYEWIQKGLEW VE
Sheep LIFLLAVSLAYEWTQKGLEW TE
Cat LISLLAASLAYEWTQKGLEW TE
Horse LISLLAISLAYEWTQKGLEW TE
Chicken IIALLTFGLIYEWTQGGLEW AE
Xenopus laevis ILTLLTLGLIYEWLQGGLEW AE
Zebrafish VLILLTLGLAYEWAQGGLEW AE
Caenorhabditis elegans FIFILG-GFYMEWWYGKLVW VI
Drosophila FILILLIGLYHEWNQGMLNW SN
Slime mold FLIILTIGFIYEIKKGALDW S-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 115 NADH-ubiquinone oxidoreductase chain 3
Assignment of a polymorphic polypeptide to the human mitochondrial DNA unidentified reading frame 3 gene by a new peptide mapping strategy.
Oliver N.A.; Greenberg B.D.; Wallace D.C.;
J. Biol. Chem. 258:5834-5839(1983)
Cited for: VARIANTS ASP-10 AND ALA-114;
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS VAL-53 AND ALA-114;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.