Variant position: 171 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 333 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GNALCTVKCDEKVKVFSVRG TSFDAAATSGGSASSEKASST
Mouse GNALCTVKCDEKVKVFSVRG TSFEAAATSGGSASSEKAPSS
Rat GNALCTVKCDEKVKVFSVRG TSFEAAAASGGSASSEKAPSS
Bovine GNAICTVKCDEKVKVFSVRG TSFEAAAASGGSASSEKASST
Caenorhabditis elegans GNAVKKVKSTAPIKLLTFRG TSFE-PAKEGGSGAVENAPSA
Slime mold GNAIATVKSTDKCKVGTVRT TAFDKAPTSGGSAKVVSANDW
Baker's yeast GNIISTIECQAEKKLLIIRA SAFP-PIAEGSMDSVTIEKRT
Fission yeast GNVNVTVSTKDPIKIVTVRA SAFDAAPSSGEGAATVVEGID
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 333 Electron transfer flavoprotein subunit alpha, mitochondrial
20 – 204 Domain I
158 – 158 N6-acetyllysine; alternate
158 – 158 N6-succinyllysine; alternate
164 – 164 N6-acetyllysine
187 – 187 N6-succinyllysine
170 – 172
A polymorphic variant in the human electron transfer flavoprotein alpha-chain (alpha-T171) displays decreased thermal stability and is overrepresented in very-long-chain acyl-CoA dehydrogenase-deficient patients with mild childhood presentation.
Bross P.; Pedersen P.; Winter V.; Nyholm M.; Johansen B.N.; Olsen R.K.; Corydon M.J.; Andresen B.S.; Eiberg H.; Kolvraa S.; Gregersen N.;
Mol. Genet. Metab. 67:138-147(1999)
Cited for: VARIANT ILE-171; CHARACTERIZATION OF VARIANT ILE-171; FUNCTION;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.