Variant position: 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 68 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MPQLNTTVWPTMITPM LLTLFLITQLKMLNTNYHLPP
Gorilla MPQLNTTVWPTMIAPM LLTLFLITQLKVLNTNYHLPP
Chimpanzee MPQLNTAVWPTMITPM LLTLFLVTQLKMLNSNYHLPP
Mouse MPQLDTSTWFITIISS MITLFILFQLKVSSQTFPLAP
Rat MPQLDTSTWFITIISS MATLFILFQLKISSQTFPAPP
Pig MPQLDTSTWFITITSM IMTLFILFQLKISNYSYPASP
Bovine MPQLDTSTWLTMILSM FLTLFIIFQLKVSKHNFYHNP
Rabbit MPQLDTSTWFTTIVAM ILSLFILMQLKFHKYTYPMNP
Goat MPQLDTSTWLTTILSM FLALFIIFQLKISKYDFYHNP
Sheep MPQLDTSTWLTMILSM FLVLFIIFQLKISKHNFYHNP
Cat MPQLDTSTWSITIMSM IMTLFIVFQLKISKYLYPSNP
Horse MPQLDTSTWFINIVSM ILTLFIVFQLKISKHSYPTHP
Chicken MPQLNPNPWFSIMLLT WFTFSLLIQPKLLSFTLTNNP
Xenopus laevis MPQLNPGPWFLILIFS WLVLLTFIPPKVLKHKAFNEP
Zebrafish MPQLNPKPWFMILFFS WVIFLTIIPTKIINHIQPNDP
Drosophila MPQMAPISWLLLFIIF SITFILFCSINYYSY-MPNSP
Baker's yeast MPQLVPF-YFMNQLTY GFLLMITLLILFSQFFLPM--
Fission yeast MPQLVPF-YFINILSF GFLIFTVLLYISSVYVLPR--
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 68 ATP synthase protein 8
8 – 24 Helical
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS PRO-17 AND SER-21;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.