Variant position: 21 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 68 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MPQLNTTVWPTMITPMLLTL FLITQLKMLNTNYHLPPSPKP
Gorilla MPQLNTTVWPTMIAPMLLTL FLITQLKVLNTNYHLPPLPKT
Chimpanzee MPQLNTAVWPTMITPMLLTL FLVTQLKMLNSNYHLPPSPKP
Mouse MPQLDTSTWFITIISSMITL FILFQLKVSSQTFPLAPSPKS
Rat MPQLDTSTWFITIISSMATL FILFQLKISSQTFPAPPSPKT
Pig MPQLDTSTWFITITSMIMTL FILFQLKISNYSYPASPESIE
Bovine MPQLDTSTWLTMILSMFLTL FIIFQLKVSKHNFYHNPELTP
Rabbit MPQLDTSTWFTTIVAMILSL FILMQLKFHKYTYPMNPVLKA
Goat MPQLDTSTWLTTILSMFLAL FIIFQLKISKYDFYHNPEL-T
Sheep MPQLDTSTWLTMILSMFLVL FIIFQLKISKHNFYHNPELMT
Cat MPQLDTSTWSITIMSMIMTL FIVFQLKISKYLYPSNPEPKS
Horse MPQLDTSTWFINIVSMILTL FIVFQLKISKHSYPTHPEVKT
Chicken MPQLNPNPWFSIMLLTWFTF SLLIQPKLLSFTLTNNPANKI
Xenopus laevis MPQLNPGPWFLILIFSWLVL LTFIPPKVLKHKAFNEPTTQT
Zebrafish MPQLNPKPWFMILFFSWVIF LTIIPTKIINHIQPNDPTQVD
Drosophila MPQMAPISWLLLFIIFSITF ILFCSINYYSY-MPNSPKSNE
Baker's yeast MPQLVPF-YFMNQLTYGFLL MITLLILFSQFFLPM------
Fission yeast MPQLVPF-YFINILSFGFLI FTVLLYISSVYVLPR------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 68 ATP synthase protein 8
8 – 24 Helical
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS PRO-17 AND SER-21;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.