Variant position: 10 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 513 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MFADRWLFS TNHKDIGTLYLLFGAWAGVLG
Chimpanzee MFTDRWLFS TNHKDIGTLYLLFGAWAGVLG
Mouse MFINRWLFS TNHKDIGTLYLLFGAWAGMVG
Rat MLVNRWLFS TNHKDIGTLYLLFGAWAGMVG
Pig MFVNRWLYS TNHKDIGTLYLLFGAWAGMVG
Bovine MFINRWLFS TNHKDIGTLYLLFGAWAGMVG
Rabbit MFVNRWLFS TNHKDIGTLYLLFGAWAGMVG
Goat MFINRWLFS TNHKDIGTLYLLFGAWAGMVG
Sheep MFINRWLFS TNHKDIGTLYLLFGAWAGMVG
Cat MFMNRWLFS TNHKDIGTLYLLFGAWAGMVG
Horse MFINRWLFS TNHKDIGTLYLLFGAWAGMVG
Chicken TFINRWLFS TNHKDIGTLYLIFGTWAGMAG
Xenopus laevis MAITRWLFS TNHKDIGTLYLVFGAWAGLVG
Zebrafish MTITRWFFS TNHKDIGTLYLVFGAWAGMVG
Caenorhabditis elegans GGLAVWLES SNHKDIGTLYFIFGLWSGMVG
Drosophila --SRQWLFS TNHKDIGTLYFIFGAWAGMVG
Slime mold IFISKWIIS VDHKNIGTMYTNFSILAGIVG
Baker's yeast -MVQRWLYS TNAKDIAVLYFMLAIFSGMAG
Fission yeast TYVNRWIFS TNAKDIAILYLLFGLVSGIIG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 513 Cytochrome c oxidase subunit 1
1 – 19 Mitochondrial matrix
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.