Variant position: 94 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 513 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSLLLLLA
Chimpanzee MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSLLLLLA
Mouse MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Rat MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Pig MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Bovine MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Rabbit MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Goat MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Sheep MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Cat MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Horse MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Chicken MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Xenopus laevis MIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Zebrafish LIGGFGNWLVPLMIGAPDMA FPRMNNMSFWLLPPSFLLLLA
Caenorhabditis elegans MIGGFGNWLLPLMLGAPDMS FPRLNNLSFWLLPTSMLLILD
Drosophila MIGGFGNWLVPLMLGAPDMA FPRMNNMSFWLLPPALSLLLV
Slime mold MLGGFANWFIPIMVGSPDVA FPRLNNISLWLIIVSFFLLLT
Baker's yeast LIGGFGNYLLPLMIGATDTA FPRINNIAFWVLPMGLVCLVT
Fission yeast LFGAFGNYLVPLMIGAPDVA YPRVNNFTFWLLPPALMLLLI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 513 Cytochrome c oxidase subunit 1
87 – 94 Mitochondrial matrix
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.