Variant position: 305 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 513 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Chimpanzee FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Mouse FIVWAHHMFTVGLDVDTRAY FTSATMIIAIPTGVKVFSWLA
Rat FIVWAHHMFTVGLDVDTRAY FTSATMIIAIPTGVKVFSWLA
Pig FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Bovine FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Rabbit FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Goat FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Sheep FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Cat FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Horse FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Chicken FIVWAHHMFTVRMDVDTRAY FTSATMIIAIPTGIKVFSWLA
Xenopus laevis FIVWAHHMFTVDLNVDTRAY FTSATMIIAIPTGVKVFSWLA
Zebrafish FIVWAHHMFTVGMDVDTRAY FTSATMIIAIPTGVKVFSWLA
Caenorhabditis elegans CVVWAHHMYTVGMDLDSRAY FSAATMVIAVPTGVKVFSWLA
Drosophila FIVWAHHMFTVGMDVDTRAY FTSATMIIAVPTGIKIFSWLA
Slime mold FLVWAHHMYTVGLDVDTRAY FTAATMIIAIPTGIKIFSWLA
Baker's yeast FLVWSHHMYIVGLDADTRAY FTSATMIIAIPTGIKIFSWLA
Fission yeast LMVWSHHLFTVGLDVDTRAY FSAATMVIAIPTGIKIFSWLA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 513 Cytochrome c oxidase subunit 1
303 – 325 Helical; Name=8
290 – 290 Copper B
291 – 291 Copper B
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS ALA-10; CYS-94; LEU-155; ALA-224 AND LEU-305;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.