Variant position: 205 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 318 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WFISTLAETNRTPFDLAEGE SELVSGFNIEYAAGPFALFFM
Gorilla WFISTLAETNRTPFDLAEGE SELVSGFNIEYAAGPLALFFM
Chimpanzee WFISTLAETNRTPFDLTEGE SELVSGFNIEYAAGPFALFFM
Mouse WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFM
Rat WYISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFM
Pig WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFAMFFM
Bovine WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFM
Rabbit WFISTLAETNRAPFDLTEGE SELVSGFNVEYAGGPFALFFL
Sheep WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFM
Cat WFISTLAETNRAPFDLTEGE SELVSGFDVEYAAGPFALFFL
Horse WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFL
Chicken WYISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFAMFFL
Xenopus laevis WYISTLAETNRAPFDLTEGE SELVSGFNVEYAGGPFALFSL
Zebrafish WFISTLAETNRAPFDLTEGE SELVSGFNVEYAAGPFALFFL
Caenorhabditis elegans ----VIAELNRAPFDFSEGE RELVRGFNVEFARVAFVLLFL
Drosophila WMSISLAETNRTPFDFAEGE SELVSGFNVEYSSGGFALIFM
Slime mold AFISALTETNRPPFDLPEAE AELVSGYNVEYSSTGFALFFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 318 NADH-ubiquinone oxidoreductase chain 1
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS PRO-205; CYS-255 AND PRO-288;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.