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UniProtKB/Swiss-Prot P03886: Variant p.Tyr255Cys

NADH-ubiquinone oxidoreductase chain 1
Gene: MT-ND1
Variant information

Variant position:  255
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Tyrosine (Y) to Cysteine (C) at position 255 (Y255C, p.Tyr255Cys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and aromatic (Y) to medium size and polar (C)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page



Sequence information

Variant position:  255
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  318
The length of the canonical sequence.

Location on the sequence:   NTLTTTIFLGTTYDALSPEL  Y TTYFVTKTLLLTSLFLWIRT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         NTLT-TTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRT

Gorilla                       NTLT-TMIFLGTTYNAHSPELYTVCFITKTLLLTSLFLWIR

                              NILT-TILFFGAFHNPFMPELYSINFTMKTLLLTICFLWIR

Chimpanzee                    NTLT-ATIFLGATYNTHSPELYTTYFVTKALLLTSLFLWIR

Mouse                         NALT-TIIFLGPLYYINLPELYSTNFMMEALLLSSTFLWIR

Rat                           NALT-SIVFLGPLYHINYPELYSTSFMTETLLLSTTFLWIR

Pig                           NAFT-AILFLGASHDPHTPELYTINFVLKTLALTITFLWIR

Bovine                        NIFT-AILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIR

Rabbit                        NALT-AILFLGSFHSHTNPEMFTVNFATKTLLLTMTFLWIR

Sheep                         NIFT-TTLFLGAFHNPYMPELYTINFTIKSLLLSITFLWIR

Cat                           NILT-TILFFGAFHSPYMPELYTINFTVKTLLLTTTFLWIR

Horse                         NIFT-TTLFLGAFHNPYLPELYSINFTIKALLLTCSFLWIR

Chicken                       NTLT-TVLFLNPSFLNLPPELFPIALATKTLLLSSSFLWIR

Xenopus laevis                NTLSYLILFLGSSF-MNQPELTTISLMIKSSILSMIFLWVR

Zebrafish                     NTHS-TVLFLGASFTPDAPELMTISIATKTAMLSILFLWMR

Caenorhabditis elegans        SVLS-SAMFFK----------FSIFMAFSIFSL---LIFIR

Drosophila                    SMLF-CVIFLGC-------DVFNLLFYMKLTFISFVFIWVR

Slime mold                    SVLL-SVFFLGGIVSN------KILGAMKGVGMLCSFIWVR

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 318 NADH-ubiquinone oxidoreductase chain 1
Transmembrane 253 – 273 Helical


Literature citations

Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS PRO-205; CYS-255 AND PRO-288;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.