Variant position: 560 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1042 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VKQKIMSVIREWGSGSDTLR CLALATHDNPLRREEMHLEDS
Mouse VKQKIMSVIREWGSGSDTLR CLALATHDNPLKREEMHLEDS
Rat VKQKIMSVIREWGSGSDTLR CLALATHDNPLRREEMHLEDS
Pig VKQKIMSVIREWGSGSDTLR CLALATHDNPMRREEMNLEDS
Rabbit VKQKIMSVIREWGSGSDTLR CLALATHDNPLRREEMHLKDS
Cat VKQKVMSVIREWGSGSDTLR CLALATHDNPLRREEMNLEDS
Chicken IKQKIMSVIREWGTGRDTLR CLALATHDNPPRKEEMNLEDS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1042 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
314 – 756 Cytoplasmic
559 – 559 ATP
580 – 580 Phosphoserine
559 – 568
ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.
Jacobsen N.J.O.; Lyons I.; Hoogendoorn B.; Burge S.; Kwok P.-Y.; O'Donovan M.C.; Craddock N.; Owen M.J.;
Hum. Mol. Genet. 8:1631-1636(1999)
Cited for: VARIANTS DD THR-39; ARG-560 AND LEU-765;
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