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UniProtKB/Swiss-Prot P05129: Variant p.Arg659Ser

Protein kinase C gamma type
Gene: PRKCG
Variant information

Variant position:  659
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Arginine (R) to Serine (S) at position 659 (R659S, p.Arg659Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  659
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  697
The length of the canonical sequence.

Location on the sequence:   SGENFDKFFTRAAPALTPPD  R LVLASIDQADFQGFTYVNPD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD

Mouse                         SGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD

Rat                           SGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD

Rabbit                        SGENFDKFFTRAAPAVTPPDRLVLASIDQADFQGFTYVNPD

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 697 Protein kinase C gamma type
Domain 615 – 685 AGC-kinase C-terminal
Modified residue 648 – 648 Phosphothreonine; by autocatalysis
Modified residue 655 – 655 Phosphothreonine; by autocatalysis
Modified residue 674 – 674 Phosphothreonine; by autocatalysis
Modified residue 675 – 675 Phosphotyrosine; by SYK


Literature citations

Segregation of a PRKCG mutation in two RP11 families.
Al-Maghtheh M.; Vithana E.N.; Inglehearn C.F.; Moore T.; Bird A.C.; Bhattacharya S.S.;
Am. J. Hum. Genet. 62:1248-1252(1998)
Cited for: VARIANTS CYS-141; GLN-415; ASP-523 AND SER-659;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.