Variant position: 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MTMHTTMTTLTLTSLI PPILTTLVN--PNKKNSYPHYVK
Gorilla MTMYATMTTLALTSLI PPILTTFIN--PNKKSSYPHY
Chimpanzee MTMYATMTTLALTSLI PPILGALIN--PNKKNSYPHY
Mouse MNIFTTSILLIFILLL SPILISMSN--LIKHINFPLY
Rat MNMMTSSILMILILLT TPIIISMTN--LPKLIDFPSY
Pig MNPFASLTLTTLIILT IPIMMSNSN--IYKTNLYPNY
Bovine MNMFSSLSLVTLLLLT MPIMMMSFN--TYKPSNYPLY
Rabbit MNLFSTSVAVSIIILV LPIVASFTN--IFNSPNYPHY
Sheep MNLFSSLTLVTLILLT MPIAAINFN--THKFTNYPLY
Cat MNLFTPLMLTAMFILL LPIIMSNTQ--LYKNSLYPHY
Horse --MFSSLMLVSLLVLT LPIMLSIFN--TYKNSTFPHH
Chicken PLLLNTLTTLTLLTLL TPIILPPLL----NLKNSPMS
Xenopus laevis PLIFNSSMLITISILI LPILMSTFN---MNIMNLHHL
Zebrafish DMIMPLTLILIFAVLS YPLLKPK----SYSKSNNSFQ
Caenorhabditis elegans ------------MNIS IFLI-----------------
Drosophila ------MCSISFVNLI SMSL-----------------
Slime mold ---------MYIVNLI LPLIGSIITGIFGHKLGNRIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 603 NADH-ubiquinone oxidoreductase chain 5
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.