Sequence information
Variant position: 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
MTMHTTMTTLTLTSLI
P PILTTLVNPNKKNSYPHYVK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MTMHTTMTTLTLTSLIP PILTTLVN--PNKKNSYPHYVK
Gorilla MTMYATMTTLALTSLIP PILTTFIN--PNKKSSYPHY
MNMFSSCMITALVILTL PIIMSSTK--LYKNKLYPYY
Chimpanzee MTMYATMTTLALTSLIP PILGALIN--PNKKNSYPHY
Mouse MNIFTTSILLIFILLLS PILISMSN--LIKHINFPLY
Rat MNMMTSSILMILILLTT PIIISMTN--LPKLIDFPSY
Pig MNPFASLTLTTLIILTI PIMMSNSN--IYKTNLYPNY
Bovine MNMFSSLSLVTLLLLTM PIMMMSFN--TYKPSNYPLY
Rabbit MNLFSTSVAVSIIILVL PIVASFTN--IFNSPNYPHY
Sheep MNLFSSLTLVTLILLTM PIAAINFN--THKFTNYPLY
Cat MNLFTPLMLTAMFILLL PIIMSNTQ--LYKNSLYPHY
Horse --MFSSLMLVSLLVLTL PIMLSIFN--TYKNSTFPHH
Chicken PLLLNTLTTLTLLTLLT PIILPPLL----NLKNSPMS
MTMYTTMTTLTLTPLIL PILTTLIN--PNKKNSYPHY
Xenopus laevis PLIFNSSMLITISILIL PILMSTFN---MNIMNLHHL
Zebrafish DMIMPLTLILIFAVLSY PLLKPK----SYSKSNNSFQ
Caenorhabditis elegans ------------MNISI FLI-----------------
Drosophila ------MCSISFVNLIS MSL-----------------
Slime mold ---------MYIVNLIL PLIGSIITGIFGHKLGNRIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 603
NADH-ubiquinone oxidoreductase chain 5
Literature citations
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.