Sequence information
Variant position: 99 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
SFKLDYFSMMFIPVALFVTW
S IMEFSLWYMNSDPNINQFFK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SFKLDYFSMMFIPVALFVTWS IMEFSLWYMNSDPNINQFFK
Gorilla SFKLDYFSMMFIPVALFVTWS IMEFSLWYMNSDPNINQFFK
SFKLNYFSMIFVPVALFVTWS IMEFSMWYMHSDPYINRFFK
Chimpanzee SFKLDYFSMTFIPVALFVTWS IMEFSLWYMDSDPNINQFFK
Mouse SFKTDFFSILFTSVALFVTWS IMQFSSWYMHSDPNINRFIK
Rat SFKIDYFSILFLSVALFVTWS IMQFSSWYMHSDPHINRFIK
Pig SFKMDYFSVMFIPVALFVTWS IMEFSMWYMHSDPFINRFFK
Bovine SFKMDYFSMMFIPVALFVTWS IMEFSMWYMYSDPNINKFFK
Rabbit SFKLDYFSMLFTPIALFVTWS IMEFSMWYMHSDPKINQFFK
Sheep SFKMDFFSMMFVPVALFVTWS IMEFSMWYMHSDPNINQFFK
Cat SFKMDYFSTIFIPVALFVTWS IMEFSMWYMHSDPYINRFFK
Horse SFKLDYFSMIFVPVALFVTWS IMEFSLWYMHSDPYITRFFK
Chicken SLKMDMYSMMFFPIALFVTWS ILEFATWYMASEPFITKFFT
SFKLDYFSMTFIPVALFVTWA IMEFSLWYMNSDPNINQFFK
Xenopus laevis SFKFDIYSSIFIPIALFVTWS ILEFATWYMASDPMISRFFK
Zebrafish SFKFDYYSVTFTSIALFITWS ILEFASWYMASYPQKELFYK
Caenorhabditis elegans KFNFYFNSILFSFILFLVTFS VLVFSTYYLNSELNFNYYYF
Drosophila TFLFDWMSLLFMSFVLMISSL VIFYSKEYMMNDNHINRFIM
Slime mold GLLYDSLTSIMIIVITCISSM VHLYSMDYMKEDPHKTRFFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 603
NADH-ubiquinone oxidoreductase chain 5
Transmembrane
87 – 107
Helical
Literature citations
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.