Variant position: 99 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SFKLDYFSMMFIPVALFVTW SIMEFSLWYMNSDPNINQFFK
Gorilla SFKLDYFSMMFIPVALFVTW SIMEFSLWYMNSDPNINQFFK
Chimpanzee SFKLDYFSMTFIPVALFVTW SIMEFSLWYMDSDPNINQFFK
Mouse SFKTDFFSILFTSVALFVTW SIMQFSSWYMHSDPNINRFIK
Rat SFKIDYFSILFLSVALFVTW SIMQFSSWYMHSDPHINRFIK
Pig SFKMDYFSVMFIPVALFVTW SIMEFSMWYMHSDPFINRFFK
Bovine SFKMDYFSMMFIPVALFVTW SIMEFSMWYMYSDPNINKFFK
Rabbit SFKLDYFSMLFTPIALFVTW SIMEFSMWYMHSDPKINQFFK
Sheep SFKMDFFSMMFVPVALFVTW SIMEFSMWYMHSDPNINQFFK
Cat SFKMDYFSTIFIPVALFVTW SIMEFSMWYMHSDPYINRFFK
Horse SFKLDYFSMIFVPVALFVTW SIMEFSLWYMHSDPYITRFFK
Chicken SLKMDMYSMMFFPIALFVTW SILEFATWYMASEPFITKFFT
Xenopus laevis SFKFDIYSSIFIPIALFVTW SILEFATWYMASDPMISRFFK
Zebrafish SFKFDYYSVTFTSIALFITW SILEFASWYMASYPQKELFYK
Caenorhabditis elegans KFNFYFNSILFSFILFLVTF SVLVFSTYYLNSELNFNYYYF
Drosophila TFLFDWMSLLFMSFVLMISS LVIFYSKEYMMNDNHINRFIM
Slime mold GLLYDSLTSIMIIVITCISS MVHLYSMDYMKEDPHKTRFFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 603 NADH-ubiquinone oxidoreductase chain 5
87 – 107 Helical
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.