Variant position: 331 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLMMVTIGINQPHLAFLHIC THAFFKAMLFMCSGSIIHNLN
Gorilla GLMVATIGIGQPHLAFLHIC THAFFKAMLFMCSGSIIHNLN
Chimpanzee GLMMVTIGINQPHLAFLHIC THAFFKAMLFMCSGSIIHNLN
Mouse GLMMVTLGMNQPHLAFLHIC THAFFKAMLFMCSGSIIHSLA
Rat GLMMVTLGINQPYLAFLHIC THAFFKAMLFMCSGSIIHSLN
Pig GLMMVTIGINQPHLAFLHIC MHAFFKAMLFMCSGSIIHSLN
Bovine GLMMVTIGINQPYLAFLHIC THAFFKAMLFMCSGSIIHSLN
Rabbit GLMMVTIGINQPHLAFLHIC THAFFKAMLFLCSGSIIHSLN
Sheep GLMMVTIGINQPHLAFLHIC THAFFKAMLFMCSGSIIHSLN
Cat GLMIVTIGINQPYLAFLHIC THAFFKAMLFMCSGSIIHSLN
Horse GLMIVTIGINQPYLAFLHIC THAFFKAMLFMCSGSIIHSLN
Chicken GLMMVTIGLDLPQLAFLHIS THAFFKAMLFLCSGLIIHSLN
Xenopus laevis GLMMVTIGL-IFQLAFFHIC NNAFFKVYYFFCSGQYSSCLN
Zebrafish GLMMVAIGLNQPHLAFFHIC THAFFKAMLFLCSGAIIHSLN
Caenorhabditis elegans GFSMVTLGLGLSFISFIHLV SHALFKSCLFMQVGYIIHCSF
Drosophila GLMMSILSMGFLKLAMFHLL THALFKALLFMCAGAIIHNMN
Slime mold GYMIFACGLLNYNASIYHLT THAFFKALLFLSAGSVIHGLN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 603 NADH-ubiquinone oxidoreductase chain 5
325 – 347 Helical
Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
Marzuki S.; Noer A.S.; Lertrit P.; Thyagarajan D.; Kapsa R.; Utthanaphol P.; Byrne E.;
Hum. Genet. 88:139-145(1991)
Cited for: VARIANTS SER-17; SER-95; PRO-99; ASP-146; VAL-160; SER-165; SER-304; ALA-331 AND GLY-503;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.