UniProtKB/SwissProt variant VAR

Variant information

Variant position:

87

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

Disease [Disclaimer]

The variants are classified into three categories: Disease, Polymorphism and Unclassified.

Disease: Variants implicated in disease according to literature reports.
Polymorphism: Variants not reported to be implicated in disease.
Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:

From Tryptophan (W) to Arginine (R) at position 87 (W87R, p.Trp87Arg).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from large size and aromatic (W) to large size and basic (R)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-3

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Involvement in disease:

Long QT syndrome 5 (LQT5) [MIM:613695]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269|PubMed:10400998, ECO:0000269|PubMed:10973849, ECO:0000269|PubMed:11692163, ECO:0000269|PubMed:16414944, ECO:0000269|PubMed:19716085, ECO:0000269|PubMed:25037568, ECO:0000269|PubMed:9354802, ECO:0000269|PubMed:9445165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

The name and a short description of the disease associated with the variant. For more information about the disease, the user can refer to OMIM, following the link provided after the disease acronym.

Variant description:

In LQT5.

Any additional useful information about the variant.

Other resources:

Links to websites of interest for the variant.

Variant rs199473361 [ dbSNP | Ensembl ]

Sequence information

Variant position:

87

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

129

The length of the canonical sequence.

Location on the sequence:

RSKKLEHSNDPFNVYIESDA W QEKDKAYVQARVLESYRSCY

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         RSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCY

Mouse                         RSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACY

Rat                           RSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACY

Pig                           RSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACY

Rabbit                        RSQKLEHSHDPFNVYIEANDWQEKDRAYFQARVLESCRGCY

Cat                           RSKKLEHSHDPFNVYIESDTWQEKDKAYLQARVLESYKACY

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 129	Potassium voltage-gated channel subfamily E member 1
Topological domain	67 – 129	Cytoplasmic
Modified residue	102 – 102	Phosphoserine; by PKC
Mutagenesis	69 – 69	K -> H. Lowers current 2-fold and leads to faster deactivation of KCNQ1/KCNE1 channel.

Literature citations

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.
Bianchi L.; Shen Z.; Dennis A.T.; Priori S.G.; Napolitano C.; Ronchetti E.; Bryskin R.; Schwartz P.J.; Brown A.M.;
Hum. Mol. Genet. 8:1499-1507(1999)
Cited for: VARIANTS JLNS2 PHE-47; HIS-51 AND ASN-76; VARIANT LQT5 ARG-87;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P15382: Variant p.Trp87Arg