Variant position: 631 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 728 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QRTVQCLSREAGGNMSIQFL GTVYKVNILTRLAAELNKFML
Mouse QRTVQCLSREAGGNMSIQFL GTVYKVHILTKLAAELNKFML
Rat QRTVQCLSPDAGGNMSIQFL GTVYKVHILTKLAAELNKFML
Pig QRTIQCLSRDAGGNMSIQFL GTVYKVHILTKLAAELNKFML
Caenorhabditis elegans HITTQIVGKRAG-EITVLYK GTPFKVKVLPEQAVKYLQYMK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
53 – 728 Propionyl-CoA carboxylase alpha chain, mitochondrial
648 – 648 N6-succinyllysine
Genetic heterogeneity in propionic acidemia patients with alpha-subunit defects: identification of five novel mutations, one of them causing instability of the protein.
Richard E.; Desviat L.R.; Perez B.; Perez-Cerda C.; Ugarte M.;
Biochim. Biophys. Acta 1453:351-358(1999)
Cited for: VARIANTS PA-1 TRP-77; THR-138; THR-164; LYS-373 AND ARG-631; CHARACTERIZATION OF VARIANTS PA-1 TRP-77; THR-138; THR-164; LYS-373 AND ARG-631; FUNCTION; SUBCELLULAR LOCATION;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.