Variant position: 159 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 413 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FKYQSLLTKNKARVIILMVW IVSGLTSFLPIQMHWYRATHQ
Rhesus macaque FKYQSLLTKNKARVIILMVW IVSGLTSFLPIQMHWYRATHQ
Mouse FKYQSLLTKNKARVVILMVW IVSGLTSFLPIQMHWYRATHK
Rat FKYQSLLTKNKARVVILMVW IVSGLTSFLPIQMHWYRATHK
Pig FKYQCLLTKNKARVVILMVW VVSGLISFLPIKMHWYQATHR
Bovine FKYQCLLTKNKARVVILMVW IVSGLTSFLPIQMHWYRASHK
Cat FKYQSLLTKNKARVVILMVW IVSGLTSFLPIQMHWYRATHQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 413 Beta-2 adrenergic receptor
151 – 174 Helical; Name=4
141 – 141 Phosphotyrosine
106 – 191
141 – 141 Y -> F. Abolishes insulin-induced tyrosine phosphorylation and insulin-induced receptor supersensitization.
147 – 170
Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.
Rupert J.L.; Monsalve M.V.; Devine D.V.; Hochachka P.W.;
Ann. Hum. Genet. 64:135-143(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLN-27; LEU-159; PHE-159 AND ARG-375;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.