Variant position: 392 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AGPPPPPPPPHPHARIKLEN PLDYGSAWAAAAAQCRYGDLA
Rhesus macaque AGPPPPPPPPHPHARIKLEN PLDYGSAWAAAAAQCRYGDLA
Chimpanzee AGPPPPPPPPHPHARIKLEN PLDYGSAWAAAAAQCRYGDLA
Mouse SGPPHPPPPTHPHARIKLEN PLDYGSAWAAAAAQCRYGDLG
Rat SGPPHPPPPTHPHARIKLEN PSDYGSAWAAAAAQCRYGDLA
Pig AGPPPPPPPPHPHARIKLEN PLDYGSAWAAAAAQCRYGDLA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 920 Androgen receptor
1 – 587 Interaction with ZNF318
1 – 559 Modulating
395 – 395 Phosphotyrosine; by CSK
388 – 388 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
1 – 532 Missing. In isoform 2.
395 – 395 Y -> F. Decrease of CSK-induced phosphorylation.
Analysis of exon 1 mutations in the androgen receptor gene.
Gottlieb B.; Vasiliou D.M.; Lumbroso R.; Beitel L.K.; Pinsky L.; Trifiro M.A.;
Hum. Mutat. 14:527-539(1999)
Cited for: VARIANTS AIS ARG-392 AND ARG-445;
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