Variant position: 570 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 848 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FEDIRHMQNEKFFRNDFS--GE VDFRDIDLTDEILTYVQDSLS
Mouse FEDIRSMQNEEFFRTDSTAAGE VDFKDIDITDEILTYVQDS
Rat FEDIRSMQNEEFFRTDSS--GE VDFKDIDITDEILTYVQDS
Rabbit FEDIKNMQNEEFFGADFS--GE VDFRDIDITDEILTYVQDS
Caenorhabditis elegans ---------------------- -------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
11 – 848 Aryl hydrocarbon receptor
Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.
Smart J.; Daly A.K.;
Cited for: VARIANTS LYS-554 AND ILE-570;
Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.
Wong J.M.Y.; Okey A.B.; Harper P.A.;
Biochem. Biophys. Res. Commun. 288:990-996(2001)
Cited for: VARIANTS SER-517 AND ILE-570;
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