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UniProtKB/Swiss-Prot P50225: Variant p.Arg37Gln

Sulfotransferase 1A1
Gene: SULT1A1
Variant information

Variant position:  37
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Glutamine (Q) at position 37 (R37Q, p.Arg37Gln).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to medium size and polar (Q)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism:  There are several alleles. The sequence shown is that of allele SULT1A1*3.
Additional information on the polymorphism described.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  37
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  295
The length of the canonical sequence.

Location on the sequence:   GVPLIKYFAEALGPLQSFQA  R PDDLLISTYPKSGTTWVSQI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQI

                              GIPLIKYFAEALESLQDFQAQPDDLLISTYPKSGTTWVSEI

Mouse                         GIPLIKYFAETMEQLQNFTAWPDDVLISTYPKSGTNWMSEI

Rat                           GIPLIKYFAETIGPLQNFTAWPDDLLISTYPKSGTTWMSEI

Bovine                        GIPLIKYFAEALGPLESFEAWPDDLLISTYPKSGTTWVSEI

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 295 Sulfotransferase 1A1
Alternative sequence 1 – 124 MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVK -> MLAKLLCDQVVGAPIAVSAFYAGMSILQGKDDIFLDLKQKFWNTYM. In isoform 2.


Literature citations

Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.
Raftogianis R.B.; Wood T.C.; Otterness D.M.; Van Loon J.A.; Weinshilboum R.M.;
Biochem. Biophys. Res. Commun. 239:298-304(1997)
Cited for: VARIANTS GLN-37; HIS-213 AND MET-223;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.