Variant position: 138 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 373 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AVYSTCMLVVLLRVQLNIIG GYIYLDNAAV----------------------------GKNGTTILAPP
Mouse AVYSTCMLVVLLRVQLNIIG GYIYLDNATV-----------
Rat AVYSTCMLVVLLRVQLNIIG GYIYLDNATV-----------
Bovine AVYSTCMLVVLLRVQLNIIG GYIYLDNAAV-----------
Slime mold VLYIIPMVTIFNRLQINLIG KYCYLDYVLY-----------
Baker's yeast VTYTVSSLILLTRLQLNILT RNEYLDSAIKLTMQQENCNKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 373 Peroxisomal biogenesis factor 3
117 – 140 Helical
125 – 125 L -> P. Abolishes binding to PEX19 without affecting targeting to peroxisomes; when associated with D-134.
134 – 134 N -> D. Abolishes binding to PEX19 without affecting targeting to peroxisomes; when associated with P-125.
100 – 142
The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.
Ghaedi K.; Tamura S.; Okumoto K.; Matsuzono Y.; Fujiki Y.;
Mol. Biol. Cell 11:2085-2102(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBCELLULAR LOCATION; VARIANT PBD10A GLU-138;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.