Variant position: 196 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 338 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human STVGAEAQEEFLRVLGSMCQ RLRSMQYNGSYFDRGAKGGSR
Mouse SMVDEAAQEEYLRVLGSMCQ KLKSVQYNGSYFDRGAEASSR
Rat SMVDAAAREEYLRVLSSMCH KLKSVQYNGSYFDRGAEASSR
Bovine SLVGAEAREEYLRLVGSMQQ KLQAAQYNSSYFDRGAKAGRR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 338 DNA fragmentation factor subunit beta
104 – 338 Missing. In isoform Delta.
117 – 338 Missing. In isoform Gamma.
Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.
Judson H.; van Roy N.; Strain L.; Vandesompele J.; Van Gele M.; Speleman F.; Bonthron D.T.;
Hum. Genet. 106:406-413(2000)
Cited for: VARIANT LYS-196;
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