Variant position: 415 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 763 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FEKLPDGTWNLKKTKDGKRE YKPPGTRKLHNILGVETGGPG
Mouse FEKLPDGTWSLKKTKDGKRE YKPPGTRKLHNILGVETGGPG
Rat FEKLPDGTWSLKKTKDGKRE YKPPGTRKLHNILGVETGGPG
Xenopus laevis FEKMPEGTWNLKKTKDGKKE YKPPGTRKLHNILGVENGGPG
Xenopus tropicalis FEKMPEGTWNLKKTKDGKKE YKPPGTRKLHNLLGVETGGPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 763 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
159 – 479 Protein kinase
408 – 442 Disordered
402 – 402 Phosphothreonine; by autocatalysis
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.
Guimera J.; Casas C.; Estivill X.; Pritchard M.A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); TISSUE SPECIFICITY; POSSIBLE INVOLVEMENT IN DOWN SYNDROME; VARIANTS PHE-415 AND HIS-681; ALTERNATIVE SPLICING;
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