Sequence information
Variant position: 34 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 649 The length of the canonical sequence.
Location on the sequence:
LTPVAKGLENMGADFLESLE
E GQLPRSDLSPAEIRSSWSEA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LTPVAKGLENMGADFLESLEE GQLPRSDLSPAEIRSSWSEA
Rat LTPMAHGLENMGAEFLESMEE GRLPHSHSSLPEGEGGLNKA
Pig LTSVANGLENMGAELLESLEE GRAPGSDSSPAEVGGGWSKA
Rabbit LSTAENGIENAG---LELTEE GINSEQTRRMEVQGHSLSDD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 649
Sodium/nucleoside cotransporter 1
Topological domain
1 – 80
Cytoplasmic
Literature citations
Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1).
Ritzel M.W.L.; Yao S.Y.M.; Huang M.-Y.; Elliott J.F.; Cass C.E.; Young J.D.;
Am. J. Physiol. 272:C707-C714(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS A GLY-34; VAL-140 INS AND ILE-189; VARIANTS B SER-409 AND ASN-521; VARIANT C ASN-521;
Genomic organization and sequence of the gene encoding the human sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1).
Ritzel M.W.L.; Ritzel R.G.; Cass C.E.; Young J.D.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT A GLY-34;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.