Variant position: 46 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 345 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IPCPRSELRLDLVLPSGQSF RWR---EQSPAHWSGVLADQVWTL
Mouse IPCPRSELRLDLVLASGQSF RWK---EQSPAHWSGVLADQV
Rat IPCPRSELRLDLVLASGQSF RWR---EQSPAHWSGVLADQV
Drosophila IGLSLEECDLERTLLGGQSF RWRSICDGNRTKYGGVVFNTY
Baker's yeast LAINKSELCLANVLQAGQSF RW---------IWDEKLNQYS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 345 N-glycosylase/DNA lyase
Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein.
Audebert M.; Radicella J.P.; Dizdaroglu M.;
Nucleic Acids Res. 28:2672-2678(2000)
Cited for: CHARACTERIZATION OF VARIANTS GLN-46 AND HIS-154;
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