Variant position: 154 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 345 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RQDPIECLFSFICSSNNNIA RITGMVERLCQAFGPRLIQLD
Mouse RQDPTECLFSFICSSNNNIA RITGMVERLCQAFGPRLIQLD
Rat RQDPTECLFSFICSSNNNIA RITGMVERLCQAFGPRLVQLD
Drosophila SQEPFENIFSFLCSQNNNIK RISSMIEWFCATFGTKIGHFN
Baker's yeast AQEPWETLISFICSSNNNIS RITRMCNSLCSNFGNLITTID
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Bruner S.D.; Norman D.P.G.; Verdine G.L.;
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 12-327 OF MUTANT GLN-247 IN COMPLEX WITH DNA; CHARACTERIZATION OF VARIANT HIS-154;
Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.
Shinmura K.; Kohno T.; Kasai H.; Koda K.; Sugimura H.; Yokota J.;
Jpn. J. Cancer Res. 89:825-828(1998)
Cited for: VARIANT HIS-154;
Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein.
Audebert M.; Radicella J.P.; Dizdaroglu M.;
Nucleic Acids Res. 28:2672-2678(2000)
Cited for: CHARACTERIZATION OF VARIANTS GLN-46 AND HIS-154;
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