Home  |  Contact

UniProtKB/Swiss-Prot O15527: Variant p.Arg154His

N-glycosylase/DNA lyase
Gene: OGG1
Chromosomal location: 3p26.2
Variant information

Variant position:  154
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Arginine (R) to Histidine (H) at position 154 (R154H, p.Arg154His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  Found in a gastric cancer sample; no effect on base-excision activity; alters substrate specificity and strongly increases mutagenic mis-repair.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  154
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  345
The length of the canonical sequence.

Location on the sequence:   RQDPIECLFSFICSSNNNIA  R ITGMVERLCQAFGPRLIQLD
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         RQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLD

Mouse                         RQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLD

Rat                           RQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLVQLD

Drosophila                    SQEPFENIFSFLCSQNNNIKRISSMIEWFCATFGTKIGHFN

Baker's yeast                 AQEPWETLISFICSSNNNISRITRMCNSLCSNFGNLITTID

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 345 N-glycosylase/DNA lyase
Binding site 149 – 149 DNA
Binding site 154 – 154 DNA
Helix 152 – 166


Literature citations

Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Bruner S.D.; Norman D.P.G.; Verdine G.L.;
Nature 403:859-866(2000)
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 12-327 OF MUTANT GLN-247 IN COMPLEX WITH DNA; CHARACTERIZATION OF VARIANT HIS-154;

Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.
Shinmura K.; Kohno T.; Kasai H.; Koda K.; Sugimura H.; Yokota J.;
Jpn. J. Cancer Res. 89:825-828(1998)
Cited for: VARIANT HIS-154;

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein.
Audebert M.; Radicella J.P.; Dizdaroglu M.;
Nucleic Acids Res. 28:2672-2678(2000)
Cited for: CHARACTERIZATION OF VARIANTS GLN-46 AND HIS-154;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.