Variant position: 6 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 400 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MDSSA APTNASNCTDA-LAYSSCSPAP
Rhesus macaque MDSSA VPTNASNCTDA-LAHSSCSPA
Chimpanzee MDSSA VPANASNCTDDALAYSSCSPA
Mouse MDSSA GPGNISDCSDP-LAPASCSPA
Rat MDSST GPGNTSDCSDP-LAQASCSPA
Pig MDSSA DPRNASNCTDPFSPSSMCSPV
Bovine MDSGA VPTNASNCTDPFTHPSSCSPA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 400 Mu-type opioid receptor
1 – 68 Extracellular
9 – 9 N-linked (GlcNAc...) asparagine
12 – 12 N-linked (GlcNAc...) asparagine
1 – 100 Missing. In isoform 12, isoform 14 and isoform 15.
1 – 96 MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIV -> MMRAKSISTKAGKPS. In isoform 13.
1 – 1 M -> MCLHRRVPSEETYSLDRFAQNPPLFPPPSLPASESRMAHAPLLQRCGAARTGFCKKQQELWQRRKEAAEALGTRKVSVLLATSHSGARPAVSTM. In isoform 10.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-6; ASP-40; CYS-147; ASP-152; CYS-265 AND ASN-274;
An homozygous Ala 6 Val (GCC->GTC) mutation was detected on human mu opioid receptor gene of an African American individual with sickle cell anemia.
Metha S.; Glendenning M.; Kutlar A.; Kutlar F.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20; VARIANT VAL-6;
Mu opioid receptor gene variants: lack of association with alcohol dependence.
Bergen A.W.; Kokoszka J.; Peterson R.; Long J.C.; Virkkunen M.; Linnoila M.; Goldman D.;
Mol. Psychiatry 2:490-494(1997)
Cited for: VARIANTS VAL-6; ASP-40 AND CYS-147;
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.
Bond C.; LaForge K.S.; Tian M.; Melia D.; Zhang S.; Borg L.; Gong J.; Schluger J.; Strong J.A.; Leal S.M.; Tischfield J.A.; Kreek M.J.; Yu L.;
Proc. Natl. Acad. Sci. U.S.A. 95:9608-9613(1998)
Cited for: VARIANTS VAL-6; ASP-40 AND HIS-260; CHARACTERIZATION OF VARIANT ASP-40; POLYMORPHISM; FUNCTION; SUBCELLULAR LOCATION;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.