Variant position: 695 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 796 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IYSTDYYRVGGRTMLPIRWM PPESILYRKFTTESDVWSFGV
Mouse IYSTDYYRVGGRTMLPIRWM PPESILYRKFSTESDVWSFGV
Rat IYSTDYYRVGGRTMLPIRWM PPESILYRKFSTESDVWSFGV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
33 – 796 High affinity nerve growth factor receptor
440 – 796 Cytoplasmic
510 – 781 Protein kinase
676 – 676 Phosphotyrosine; by autocatalysis
680 – 680 Phosphotyrosine; by autocatalysis
681 – 681 Phosphotyrosine; by autocatalysis
Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies.
Shatzky S.; Moses S.; Levy J.; Pinsk V.; Hershkovitz E.; Herzog L.; Shorer Z.; Luder A.; Parvari R.;
Am. J. Med. Genet. 92:353-360(2000)
Cited for: VARIANT CIPA LEU-695; VARIANT VAL-613;
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