Sequence information
Variant position: 548 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
MDSYSGPYGDMRLETARDHV
L PIDYYFPPQKTCLICGDEAS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MDSYSGPYGDMRLETARDHVL PIDYYFPPQKTCLICGDEAS
MESYSGPYGDMRLETARDHVL PIDYYFPPQKTCLICGDEAS
Rhesus macaque MDSYSGPYGDMRLETARDHVL PIDYYFPPQKTCLICGDEAS
Chimpanzee MDSYSGPYGDMRLETARDHVL PIDYYFPPQKTCLICGDEAS
Mouse MENYSGPYGDMRLDSTRDHVL PIDYYFPPQKTCLICGDEAS
Rat MENYSGPYGDMRLDSTRDHVL PIDYYFPPQKTCLICGDEAS
Pig MESYSGPYGDMRLEPTRDHVL PIDYYFPPQKTCLICGDEAS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 920
Androgen receptor
Region
1 – 587
Interaction with ZNF318
Region
1 – 559
Modulating
Modified residue
535 – 535
Phosphotyrosine; by CSK
Modified residue
552 – 552
Phosphotyrosine; by CSK
Mutagenesis
535 – 535
Y -> F. Greatest decrease of CSK-induced phosphorylation and inhibition of transcriptional activity induced by EGF.
Mutagenesis
552 – 552
Y -> F. Decrease in CSK-induced phosphorylation.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.