Variant position: 560 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LETARDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Rhesus macaque LETARDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Chimpanzee LETARDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Mouse LDSTRDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Rat LDSTRDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Pig LEPTRDHVLPIDYYFPPQKT CLICGDEASGCHYGALTCGSC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 920 Androgen receptor
560 – 632 Nuclear receptor
560 – 580 NR C4-type
1 – 587 Interaction with ZNF318
552 – 919 Interaction with LPXN
552 – 552 Phosphotyrosine; by CSK
552 – 552 Y -> F. Decrease in CSK-induced phosphorylation.
Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
Zoppi S.; Marcelli M.; Deslypere J.-P.; Griffin J.E.; Wilson J.D.; McPhaul M.J.;
Mol. Endocrinol. 6:409-415(1992)
Cited for: VARIANTS AIS TYR-560 AND ARG-577; VARIANTS PAIS GLY-598 AND PRO-618;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.