Variant position: 577 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Rhesus macaque QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Chimpanzee QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Mouse QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Rat QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Pig QKTCLICGDEASGCHYGALT CGSCKVFFKRAAEGKQKYLCA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.
Zoppi S.; Marcelli M.; Deslypere J.-P.; Griffin J.E.; Wilson J.D.; McPhaul M.J.;
Mol. Endocrinol. 6:409-415(1992)
Cited for: VARIANTS AIS TYR-560 AND ARG-577; VARIANTS PAIS GLY-598 AND PRO-618;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.