Variant position: 583 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Rhesus macaque CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Chimpanzee CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Mouse CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Rat CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Pig CGDEASGCHYGALTCGSCKV FFKRAAEGKQKYLCASRNDCT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 920 Androgen receptor
560 – 632 Nuclear receptor
1 – 587 Interaction with ZNF318
552 – 919 Interaction with LPXN
572 – 662 Interaction with HIPK3
Detection of point mutations in the androgen receptor gene using non-isotopic single strand conformation polymorphism analysis.
Hiort O.; Wodtke A.; Struve D.; Zoellner A.; Sinnecker G.H.;
Hum. Mol. Genet. 3:1163-1166(1994)
Cited for: VARIANTS PAIS SER-583; TYR-605; ALA-709; LEU-755 AND HIS-772; VARIANT AIS TRP-780;
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