Variant position: 602 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Rhesus macaque VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Chimpanzee VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Mouse VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Rat VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Pig VFFKRAAEGKQKYLCASRND CTIDKFRRKNCPSCRLRKCYE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Two mutations causing complete androgen insensitivity: a frame-shift in the steroid binding domain and a Cys-->Phe substitution in the second zinc finger of the androgen receptor.
Baldazzi L.; Baroncini C.; Pirazzoli P.; Balsamo A.; Capelli M.; Marchetti G.; Bernardi F.; Cacciari E.;
Hum. Mol. Genet. 3:1169-1170(1994)
Cited for: VARIANT AIS PHE-602;
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