Variant position: 813 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Rhesus macaque QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Chimpanzee QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Mouse QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Rat QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Pig QEFGWLQITPQEFLCMKALL LFSIIPVDGLKNQKFFDELRM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 920 Androgen receptor
669 – 900 NR LBD
552 – 919 Interaction with LPXN
592 – 919 Interaction with CCAR1
625 – 919 Interaction with KAT7
645 – 920 Missing. In isoform 3.
649 – 920 Missing. In isoform 4.
Point mutations in the steroid-binding domain of the androgen receptor gene of five Japanese patients with androgen insensitivity syndrome.
Yaegashi N.; Uehara S.; Senoo M.; Sato J.; Fujiwara J.; Funato T.; Sasaki T.; Yajima A.;
Tohoku J. Exp. Med. 187:263-272(1999)
Cited for: VARIANTS AIS PHE-813 AND GLN-832;
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