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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P10275: Variant p.Arg872Gly

Androgen receptor
Gene: AR
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Variant information Variant position: help 872 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Arginine (R) to Glycine (G) at position 872 (R872G, p.Arg872Gly). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to glycine (G) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In AIS. Any additional useful information about the variant.


Sequence information Variant position: help 872 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 920 The length of the canonical sequence.
Location on the sequence: help SCSRRFYQLTKLLDSVQPIA R ELHQFTFDLLIKSHMVSVDF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

                              SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

Rhesus macaque                SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

Chimpanzee                    SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

Mouse                         SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

Rat                           SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF

Pig                           SCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDF
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 920 Androgen receptor
Domain 669 – 900 NR LBD
Region 552 – 919 Interaction with LPXN
Region 592 – 919 Interaction with CCAR1
Region 625 – 919 Interaction with KAT7
Binding site 878 – 878
Alternative sequence 645 – 920 Missing. In isoform 3.
Alternative sequence 649 – 920 Missing. In isoform 4.
Helix 850 – 883



Literature citations
Discordant measures of androgen-binding kinetics in two mutant androgen receptors causing mild or partial androgen insensitivity, respectively.
Shkolny D.L.; Beitel L.K.; Ginsberg J.; Pekeles G.; Arbour L.; Pinsky L.; Trifiro M.A.;
J. Clin. Endocrinol. Metab. 84:805-810(1999)
Cited for: VARIANT PAIS ALA-773; VARIANT AIS GLY-872;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.