Variant position: 918 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EIISVQVPKILSGKVKPIYF HTQ
Rhesus macaque EIISVQVPKILSGKVKPIYF HTQ
Chimpanzee EIISVQVPKILSGKVKPIYF HTQ
Mouse EIISVQVPKILSGKVKPIYF HTQ
Rat EIISVQVPKILSGKVKPIYF HTQ
Pig EIISVQVPKILSGKVKPIYF HTQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 920 Androgen receptor
552 – 919 Interaction with LPXN
592 – 919 Interaction with CCAR1
625 – 919 Interaction with KAT7
898 – 898 Interaction with coactivator FXXLF and FXXFY motifs
916 – 916 Phosphotyrosine; by CSK
645 – 920 Missing. In isoform 3.
649 – 920 Missing. In isoform 4.
898 – 898 E -> AQ. Reduced transcription activation in the presence of androgen.
898 – 898 E -> KR. Loss of transcription activation in the presence of androgen.
916 – 916 Y -> F. Decrease in CSK-induced phosphorylation.
No reference for the current variant in UniProtKB/Swiss-Prot.
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