Variant position: 49 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 477 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AARLLVPASPPASLLPPASE SPEPLSQQWTAGMGLLMALIV
Rhesus macaque AARLLVPASPPASLLPPASE GPEPLSQQWTAGMGLLMALIV
Mouse AARLLVLASPPASLLPPASE GSAPLSQQWTAGMGLLLALIV
Rat AARLLVLASPPASLLPPASE GSAPLSQQWTAGMGLLLALIV
Pig AARLLVPASPPASLLTPASE GSVQLSQQWTAGMGLLMALIV
Bovine AARLLVPASPPASLLTSASE GPPLPSQQWTAGMGLLMAFIV
Sheep AARLLVPXSPLRLAADLGQR GTPLLSQQWTVGMGLLMAFIV
Cat AARLLVPASPSASPLTPTSE GPAPLSQQWTAGIGLLMALIV
Xenopus laevis ------PTTVPSPMHPL--- --PELTHQWTMGMTMFMAAII
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 477 Beta-1 adrenergic receptor
1 – 55 Extracellular
Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.
Moore J.D.; Mason D.A.; Green S.A.; Hsu J.; Liggett S.B.;
Hum. Mutat. 14:271-271(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLY-49 AND GLY-389;
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLY-49; GLY-389 AND LEU-389;
A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.
Borjesson M.; Magnusson Y.; Hjalmarson A.; Andersson B.;
Eur. Heart J. 21:1853-1858(2000)
Cited for: VARIANT GLY-49;
A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.
Ranade K.; Jorgenson E.; Sheu W.H.-H.; Pei D.; Hsiung C.A.; Chiang F.-T.; Chen Y.-D.I.; Pratt R.; Olshen R.A.; Curb D.; Cox D.R.; Botstein D.; Risch N.;
Am. J. Hum. Genet. 70:935-942(2002)
Cited for: VARIANT GLY-49;
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