Variant position: 98 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 129 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FNVYIESDAWQEKDKAYVQA RVLESYRSCYVVENHLAIEQP
Mouse FNVYIESDAWQEKGKAVFQA RVLESFRACYVIENQAAVEQP
Rat FNVYIESDAWQEKGKALFQA RVLESFRACYVIENQAAVEQP
Pig FNVYIESDAWQEKGKALFQA RVLESFRACYAIENQAAVEQP
Rabbit FNVYIEANDWQEKDRAYFQA RVLESCRGCYVLENQLAVEHP
Cat FNVYIESDTWQEKDKAYLQA RVLESYKACYVIENQLAVERP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 129 Potassium voltage-gated channel subfamily E member 1
67 – 129 Cytoplasmic
102 – 102 Phosphoserine; by PKC
92 – 105
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2.
Splawski I.; Shen J.; Timothy K.W.; Lehmann M.H.; Priori S.G.; Robinson J.L.; Moss A.J.; Schwartz P.J.; Towbin J.A.; Vincent G.M.; Keating M.T.;
Cited for: VARIANTS LQT5 HIS-32; TRP-98 AND THR-127;
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