Variant position: 102 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 159 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AAYLNPCSA---MDYSLAAALTL HGHWGLGQVVTDY----VHGDALQK
Mouse AGYLNPCSV---VDYSLAAALTL HSHWGLGQVVTDY----V
Rat AGYLNPCSV---VDYSLAAALTL HSHWGIGQVVTDY----V
Pig AAYLNPCSA---MDYSLAAALTL HGHWGIGQVVTDY----V
Bovine AAYLNPCSA---MDYSLAATLTL HSHWGIGQVVTDY----V
Sheep AAYLNPCSA---MDYSLAATLTL HSHWGIGQVVTDY----V
Chicken AAYLYPGPA---VDYSLAAALTL HGHWGLGQVITDY----V
Xenopus tropicalis AAYLYPGAA---MDYSLAAALTL HGHWGLGQVVTDY----V
Caenorhabditis elegans ASYFIHGPV---MDAVLTVALTL HIHWGIHGVVYDYARPYV
Drosophila AAFIAPSQV---LDALMAISVVI HTHWGVEAMVVDYMRPSV
Baker's yeast TAMLTTGPLSTAADSFFSVMLLG YCYMEFNSCITDYISERV
Fission yeast LFTGTSHPL---MDAALACTLIT HAHLGFESCVIDYFPARR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
57 – 159 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
91 – 111 Helical
102 – 102 Iron (heme axial ligand); shared with SDHC
114 – 114 Ubiquinone; shared with IP/SDHB
56 – 158 HSGSKAASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDALQKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWK -> HWALDKLLLTMFMGMPCRKLPRQGFWHFQ. In isoform 3.
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.
Baysal B.E.; Ferrell R.E.; Willett-Brozick J.E.; Lawrence E.C.; Myssiorek D.; Bosch A.; van der Mey A.; Taschner P.E.M.; Rubinstein W.S.; Myers E.N.; Richard C.W. III; Cornelisse C.J.; Devilee P.; Devlin B.;
Cited for: VARIANTS PGL1 LEU-81; TYR-92 AND LEU-102;
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