Variant position: 495 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 503 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YPSKLARNESRSGSNRRERG APPLPPIPR
Mouse YPSKLARNESRSGSNRRERG APPLPPIPR
Rat YPSKVARSESRSGSNRRERG APPLPPIPR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 503 WAS/WASL-interacting protein family member 1
487 – 503 GSNRRERGAPPLPPIPR -> EYFCQGF. In isoform 2.
503 – 503 R -> RPPKQAAE. In isoform 3.
WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.
Ramesh N.; Anton I.M.; Hartwig J.H.; Geha R.S.;
Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS LEU-198 AND GLY-495; FUNCTION; TISSUE SPECIFICITY; INTERACTION WITH WASP; PROFILIN AND ACTIN;
Kreideweiss S.; Delany-Heiken P.; Nordheim A.; Ruhlmann A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANTS LEU-198 AND GLY-495;
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