Variant position: 472 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 500 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QKANEQ-KKESKEEETSIDVA GKPNEVTKAAESPDQKDTDGG------
Mouse QKAEEKQKREGKEDEASTDVD EKPKETMKAAQSPQ--QHSS
Rat QKAEEK-KRDGKEDETSTDVD EKPKKTMKETQSPAPLQNSS
Bovine QKAEKQQKKESKDEETNVDVA EKPKEVIDAAESPEHKATEE
Baker's yeast PDNVTSQDNEEKNNGDSQAAK GMEDIANETGLTGKAKEALG
Fission yeast TTADEQQTVQNIDKEESEDAA GR-------GLSGTSKKALE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 500 Monocarboxylate transporter 1
444 – 500 Cytoplasmic
461 – 461 Phosphoserine
466 – 466 Phosphothreonine
467 – 467 Phosphoserine
483 – 483 Phosphoserine
411 – 500 RLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV -> IVYLPTNVGLLQNKHVRWEC. In isoform 2.
Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport.
Merezhinskaya N.; Fishbein W.N.; Davis J.I.; Foellmer J.W.;
Muscle Nerve 23:90-97(2000)
Cited for: VARIANTS SDLT GLU-204 AND ARG-472; VARIANT GLU-490;
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