Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 301 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ISHDTRRFRFALPSPQHILG LPVGQHIYLSARIDGNLVVRP
Mouse ISPDTRRFRFALPSPQHILG LPIGQHIYLSTRIDGNLVIRP
Rat ISHDTRRFRFALPSPQHILG LPIGQHIYLSTRIDGNLVIRP
Bovine ISHDTRRFRFALPSPEHILG LPVGQHIYLSARIDGNLVIRP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 301 NADH-cytochrome b5 reductase 3 membrane-bound form
27 – 301 NADH-cytochrome b5 reductase 3 soluble form
40 – 152 FAD-binding FR-type
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT PRO-66; VARIANTS HM GLN-58; PRO-73 AND TYR-204;
Identification of a novel point mutation (Leu72-to-Pro) in the NADH-cytochrome b5 reductase gene of a patient with hereditary methaemoglobinaemia type I.
Wu Y.-S.; Huang C.-H.; Wan Y.; Huang Q.-J.; Zhu Z.-Y.;
Br. J. Haematol. 102:575-577(1998)
Cited for: VARIANT METHB-CYB5R3 PRO-73;
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