Variant position: 117 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 301 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ISSDDDKGFVDLVIKVYFKD THPKFPAGGKMSQYLESMQIG
Mouse VSSDDDKGFVDLVVKVYFKD THPKFPAGGKMSQYLENMKIG
Rat VSSDDDKGFVDLVVKVYFKD THPKFPAGGKMSQYLENMNIG
Bovine VSSDDDKGFVDLVIKVYFKD THPKFPAGGKMSQYLESMKIG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 301 NADH-cytochrome b5 reductase 3 membrane-bound form
27 – 301 NADH-cytochrome b5 reductase 3 soluble form
40 – 152 FAD-binding FR-type
120 – 120 N6-acetyllysine
115 – 118
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT SER-117;
A high-frequency polymorphism of NADH-cytochrome b5 reductase in African-Americans.
Jenkins M.M.; Prchal J.T.;
Hum. Genet. 99:248-250(1997)
Cited for: VARIANT SER-117;
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