Variant position: 2702 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 3056 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TIQSFKAEFRLAG-GVNLPKI IDCVGSDGKERRQLVKG-RDDL
Mouse TIKSFKTEFRLAG-GLNLPKI IDCVGSDGKERRQLVKG-RD
Pig TIQSFKPEFRLAG-GLNLPKI IDCVGSDGKERRQLVKG-RD
Caenorhabditis elegans TWKRWKDVFTIAD-GISTPKI WEIEGSDGKWYKTVWK--KD
Drosophila SVVKWTNETTQCG-GLNAPVK IMCVCSDGKIRAQLVKG-KD
Baker's yeast YIVSVNETVGITTTGLSLPKI VTFNISDGTTQKALMKGSND
Fission yeast TVSSFDDTIHFAS-GINAPKV ITCLGSNGHTYKQLVKGGND
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 3056 Serine-protein kinase ATM
2686 – 2998 PI3K/PI4K catalytic
2685 – 2685 S -> T. No effect on phosphorylation of target proteins.
2699 – 2699 P -> L. Loss of phosphorylation of target proteins.
2708 – 2708 D -> N. Decreased phosphorylation of target proteins.
2700 – 2709
No reference for the current variant in UniProtKB/Swiss-Prot.
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