Variant position: 116 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 494 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CINNGKSIFEARLDIDISWQ CLEYYAGLAASMAGEHIQLPG
Mouse TINNGKSIFEARLDVDTCWQ CLEYYAGLAASMAGEHIQLPG
Rat TINNGKSIFEARLDVDTSWQ CLEYYAGLAASMAGEHIQLPG
Pig TINNGKSIFEARLDVDISWQ CLEYYAGLAGSMAGEHIQLPG
Bovine TINNGKSIFEARWDIDTSWQ CLEYYAGLAGSMAGEHIQLPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 494 4-trimethylaminobutyraldehyde dehydrogenase
2 – 494 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed
103 – 126
Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression.
Lin S.W.; Chen J.C.; Hsu L.C.; Hsieh C.-L.; Yoshida A.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT SER-116;
Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution.
Kikonyogo A.; Pietruszko R.;
Biochem. J. 316:317-324(1996)
Cited for: PROTEIN SEQUENCE OF 259-274; 353-366; 412-426 AND 434-453; NUCLEOTIDE SEQUENCE [MRNA] OF 29-494; FUNCTION; CATALYTIC ACTIVITY; BIOPHYSICOCHEMICAL PROPERTIES; TISSUE SPECIFICITY; VARIANT SER-116;
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