Variant position: 87 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 318 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TITLYITAPTLALTIALLLW TPLPMPNP--LVNLNLGLLFILA
Gorilla TITLYITAPTLALTIALLLW TPLPMPNP--LVNLNLGLLFI
Chimpanzee TITLYITAPTLALTIALLLW TPLPMPNP--LVNLNLGLLFI
Mouse SMSLFIIAPTLSLTLALSLW VPLPMPHP--LINLNLGILFI
Rat SMSLFIIAPTLSLTLALSLW IPLPMPHP--LINLNLGMLFI
Pig SISMFIIAPILALSLALTMW VPLPMPYP--LINMNLGVLFM
Bovine SASMFILAPIMALGLALTMW IPLPMPYP--LINMNLGVLFM
Rabbit SPLLFIIAPTLALTLALSMW LPIPMPYP--LVNLNMGILFI
Sheep SISMFILAPILALTLALTMW IPLPMPYP--LINMNLGVLFM
Cat SMLMFIMAPILALTLALTMW IPLPMPYP--LINMNLGVLFM
Horse STSMFIIAPILALTLALTMW IPLPMPYP--LINMNLGILFM
Chicken SPFLFIITPILALLLALTIW VPLPLPFP--LADLNLGLLFL
Xenopus laevis SQTMFLIAPTMALALAMSIW APLPMPFS--LADLNLGILFI
Zebrafish SPILFLTAPVLALILAMMLW APMPMPYP--VLDLNLGILFI
Caenorhabditis elegans SEVSFLLVPGISFVVMYLEW FTLPYFFD--FISFEYSVLFF
Drosophila NYLSYYISPIFSLFLSLFVW MCMPFFVK--LYSFNLGGLFF
Slime mold DKLIYAIAPILTFTISIVLW SVIAVGVQSVFASINSGVIFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 318 NADH-ubiquinone oxidoreductase chain 1
68 – 88 Helical
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
Horai S.; Hayasaka K.; Kondo R.; Tsugane K.; Takahata N.;
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-87 AND ALA-168;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.