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UniProtKB/Swiss-Prot P03886: Variant p.Thr87Ala

NADH-ubiquinone oxidoreductase chain 1
Gene: MT-ND1
Chromosomal location: M
Variant information

Variant position:  87
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Threonine (T) to Alanine (A) at position 87 (T87A, p.Thr87Ala).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and polar (T) to small size and hydrophobic (A)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  87
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  318
The length of the canonical sequence.

Location on the sequence:   TITLYITAPTLALTIALLLW  T PLPMPNPLVNLNLGLLFILA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         TITLYITAPTLALTIALLLWTPLPMPNP--LVNLNLGLLFILA

Gorilla                       TITLYITAPTLALTIALLLWTPLPMPNP--LVNLNLGLLFI

                              SMSMFILAPILALSLALTMWIPLPMPYP--LINMNLGVLFM

Chimpanzee                    TITLYITAPTLALTIALLLWTPLPMPNP--LVNLNLGLLFI

Mouse                         SMSLFIIAPTLSLTLALSLWVPLPMPHP--LINLNLGILFI

Rat                           SMSLFIIAPTLSLTLALSLWIPLPMPHP--LINLNLGMLFI

Pig                           SISMFIIAPILALSLALTMWVPLPMPYP--LINMNLGVLFM

Bovine                        SASMFILAPIMALGLALTMWIPLPMPYP--LINMNLGVLFM

Rabbit                        SPLLFIIAPTLALTLALSMWLPIPMPYP--LVNLNMGILFI

Sheep                         SISMFILAPILALTLALTMWIPLPMPYP--LINMNLGVLFM

Cat                           SMLMFIMAPILALTLALTMWIPLPMPYP--LINMNLGVLFM

Horse                         STSMFIIAPILALTLALTMWIPLPMPYP--LINMNLGILFM

Chicken                       SPFLFIITPILALLLALTIWVPLPLPFP--LADLNLGLLFL

Xenopus laevis                SQTMFLIAPTMALALAMSIWAPLPMPFS--LADLNLGILFI

Zebrafish                     SPILFLTAPVLALILAMMLWAPMPMPYP--VLDLNLGILFI

Caenorhabditis elegans        SEVSFLLVPGISFVVMYLEWFTLPYFFD--FISFEYSVLFF

Drosophila                    NYLSYYISPIFSLFLSLFVWMCMPFFVK--LYSFNLGGLFF

Slime mold                    DKLIYAIAPILTFTISIVLWSVIAVGVQSVFASINSGVIFI

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 318 NADH-ubiquinone oxidoreductase chain 1
Transmembrane 68 – 88 Helical


Literature citations

Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
Horai S.; Hayasaka K.; Kondo R.; Tsugane K.; Takahata N.;
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-87 AND ALA-168;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.