Variant position: 168 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 318 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IILLSTLLMSGSFNLSTLIT TQEHLWLLLPSWPLAMMWFIS
Gorilla IILLSTLLMNGSFNLSTLIM TQEHLWLLLPTWPLAMMWFIS
Chimpanzee IILLSTLLMSGSFNLSTLVT TQEHLWLILPTWPLAMMWFIS
Mouse IILLSVLLMNGSYSLQTLIT TQEHMWLLLPAWPMAMMWFIS
Rat IILLSVLLMSGSFSLQMLIT TQEHIWLLIPAWPMAMMWYIS
Pig IILLSVLLMNGSYTLSTLIT TQEHIWMIFTSWPLAMMWFIS
Bovine IILLSVLLMSGSFTLSTLIT TQEQMWLILPAWPLAMMWFIS
Rabbit IILLCILLMNGSFTLSSLIT TQEYMWILLPAWPLAMMWFIS
Sheep IILLSVLLMNGSFTLSTLII TQEQVWLIFPAWPLAMMWFIS
Cat IILLSVLLMNGSFTLAMLIT TQEYMWLIIPAWPLAMMWFIS
Horse IILLSVLLMSGSFTLSTLII TQEYLWLIFPSWPLAMMWFIS
Chicken IILLSTIMLSGNYTLSTLAI TQEPIYLIFSAWPLAMMWYIS
Xenopus laevis LILLCMIMLAGGFTYTTLMT TQEQMWLIIPGWPMAAMWYIS
Zebrafish LILLSAVIFSGGYTLQTFNT TQEDTWLLLPLWPLAIMWFIS
Caenorhabditis elegans LYVLCIIIHNNVFN----FV SKFNLSLLIIYIPFLIM----
Drosophila LILLSFIFLIGSYNMIYFFF YQVYMWFLIILFPMALVWMSI
Slime mold LIILSIITYAGTVNLQEIME NQEKVWFIIPLLPGFLLAFIS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 318 NADH-ubiquinone oxidoreductase chain 1
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
Horai S.; Hayasaka K.; Kondo R.; Tsugane K.; Takahata N.;
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-87 AND ALA-168;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.