Sequence information
Variant position: 211 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 603 The length of the canonical sequence.
Location on the sequence:
LHSNSWDPQQMALLNANPSL
T PLLGLLLAAAGKSAQLGLHP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LHSNSWDPQQMA------------LLNAN-PSLT PLLG--LLLAAAGKSAQLGLHP
Gorilla LHSNSWDPQQMS------------LLNTN-PNLI PLLG--F
LNLNTWDLQQIF------------ITTND-NFNL PLLG--L
Chimpanzee LHSNSWDPQQMI------------LLSTN-TDLT PLLG--F
Mouse LNMNSWELQQIM------------FSNNN-DNLI PLMG--L
Rat LNMNSWELQQIF------------LTNTN--NLV PLTG--L
Pig THSNAWDLQQIF------------MLNNE-CPNM PLIG--L
Bovine TNLNTWDLQQIF------------MLNPS-DSNM PLIG--L
Rabbit INLNTWELQQIF------------ILDNN-ITIL PLMG--L
Sheep INLNTWDLQQIF------------MLNPN-DSNL PLMG--L
Cat TNSNAWDFQQIF------------ITQHE-NLNI PLLG--L
Horse FNTNTWDLQQIF------------MLDPN-LTNL PLLG--L
Chicken SSLNTWEIQQIT------------HPN-Q-TPTL PLLG--L
LHSNSWDPQQMV------------LLSTN-PSLT PLLG--F
Xenopus laevis MNLNSWEMQQVF------------MLNSD-NLTL PLLG--L
Zebrafish MYLNSWDIQQIF------------ILSKDFDMTI PQIG--L
Caenorhabditis elegans SVFSGYYFLSFS------------MFSSY----M SLL---L
Drosophila LNYGSWNYIFYL------------EIMQN-EFEM LMIGSLV
Slime mold LVFKSVDFSVIFTIAPFITEYTINLLGYE-VNAI TLIGSFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 603
NADH-ubiquinone oxidoreductase chain 5
Transmembrane
211 – 233
Helical
Literature citations
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
Horai S.; Hayasaka K.; Kondo R.; Tsugane K.; Takahata N.;
Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS PRO-211; VAL-257 AND VAL-314;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.