Variant position: 133 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 467 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GRLQVSHRKGLPHVIYCRLW RWPDLHSHHELKAIENCEYAF
Mouse GRLQVSHRKGLPHVIYCRLW RWPDLHSHHELKAIENCEYAF
Rat GRLQVSHRKGLPHVIYCRLW RWPDLHSHHELKAIENCEYAF
Bovine GRLQVSHRKGLPHVIYCRLW RWPDLHSHHELKAIENCEYAF
Zebrafish GRLQVSHRKGLPHVIYCRLW RWPDLHSHHELRAIETCEYAF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 467 Mothers against decapentaplegic homolog 2
10 – 176 MH1
149 – 149 Zinc
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Eppert K.; Scherer S.W.; Ozcelik H.; Pirone R.; Hoodless P.; Kim H.; Tsui L.-C.; Bapat B.; Gallinger S.; Andrulis I.L.; Thomsen G.H.; Wrana J.L.; Attisano L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG); PHOSPHORYLATION BY TGFBR1; VARIANTS CYS-133; ARG-440; HIS-445 AND GLU-450;
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